What Causes High Alkaline Phosphatase in Blood Test
Alkaline Phosphatase Blood Test — Alkaline Phosphatase (ALP) is an enzyme that is found in all the tissues of our body.
But its highest quantity is found in bones, liver, kidney, intestine, and placenta.
About 80% of alkaline phosphatase is found in our liver and bone, and the remaining 20% is found in the kidney, intestine, and placenta.
What is the Function of Alkaline Phosphatase in Liver
Alkaline phosphatase performs many functions in our body. It helps in digesting our food and keeping our bones strong.
Transports nutrients and enzymes to and from the liver.
ALP helps in the development of bones and in maintaining them healthy.
ALP helps to transport calcium and phosphate from our intestines to our bones, muscles, and nerve cells so that they can perform their normal functions.
ALP helps in the transportation of fatty acids too so that energy can be stored in adipose tissue.
It helps in the cell development of babies during pregnancy.
It also prevents the cell from getting damaged.
Why is Alkaline Phosphatase Test Done
Alkaline phosphatase test is done by the doctor to find out the condition of your liver and bones.
If there is any problem in your liver and bone, this test helps the doctor to diagnose further disease.
However, the increase or decrease of ALP alone does not indicate any disease, for this, the doctor also prescribes other tests to get an idea of the correct condition.
What is the Normal Range of Alkaline Phosphatase Blood Test
The normal value of alkaline phosphatase in our blood is 20 U/L to 140 U/L. This value varies from lab to lab.
Its value increases in growing children and during pregnancy.
People with HIV or women who take birth control pills also have abnormal levels.
What Causes High Alkaline Phosphatase in Blood
Higher-than-normal levels of alkaline phosphatase (ALP) may indicate liver or bone problems, for example
1) Hepatitis
2) Liver cancer
3) liver cirrhosis
4) Bile duct blockage
5) Gallbladder inflammation
6) Vitamin D and calcium deficiency
7) Paget’s Disease
8) Bone Cancer
9) Osteoporosis
10) Heart failure
What Causes Low Alkaline Phosphatase in Blood
Low level of alkaline phosphatase also indicates many diseases like
1) Malnutrition
2) Zinc and magnesium deficiency
3) Autoimmune anemia
4) Wilson’s disease
5) Ulcerative Colitis
6) Crohn’s disease
7) Celiac disease
8) Aplastic anemia
9) Dwarfism
10) Hypophosphatasia
Symptoms of Abnormal Alkaline Phosphatase (ALP)
1) Nausea
2) Weight loss
3) Fatigue
4) Weakness
5) Jaundice
6) Abdominal pain
7) Persistent itching
8) Dark urine
9) Pain in the joints of the bones
10) Dislocation of bones or formation of lumps
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